人类雌激素受体ɑ基因多态性与稽留流产关系的研究被引量：1

Study on the association of estrogen receptor gene polymorphism with missed abortion.

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摘要目的研究探讨雌激素受体ɑ(estrogen receptor alpha,ERɑ)基因多态性与稽留流产的关系。方法选取稽留流产患者73例,选取正常妊娠要求流产者95例作为对照组。采集个体妊娠绒毛组织,用分子生物学方法,分析内切酶PvuII、XbaI限制性片段长度多态性(restriction fragment length polymorphism,RFLP),观察ERɑ基因多态性在实验组与对照组中的基因型分布及等位基因频率。通过统计学分析探讨ERɑ基因多态性分布与稽留流产的关系。结果 ERɑ基因PvuII酶切多态性分布在实验组与对照组组间差异有统计学意义(P<0·05),ERɑ基因XbaI酶切多态性基因型分布在实验组中不符合Hardy-Weinberg平衡。结论 ERɑ基因PvuII酶切多态性与稽留流产有关系。P等位基因可能是其危险因素。 Objective：To investigate the relationship between estrogen receptor alpha（ERɑ） gene polymorphism and missed abortion.Methods：XbaI,and PvuII polymorphism of ERɑ gene were studied by polymerase chain reaction-re-striction fragment lengh polymorphism（PCR-RFLP） of Peripheral blood and chorionic villus in 73 patients with missed abortion and normal control.The relationship between missed abortion and polymorphism of ERɑ gene was analyzed by variance analysis.Results： PvuII polymorphisim of ERɑ gene is significantly associated with recurrent abortion（P0.05）.Conclusions：There is a significant correlation of PvuII polymorphisim of ERɑ gene to missed abortion.It implies that the difference in ERɑ genotypes among individuals might influence the development of embryo.

作者刘莎其木格

机构地区内蒙古医学院第一附属医院妇产科

出处《中国优生与遗传杂志》 2010年第10期16-18,共3页 Chinese Journal of Birth Health & Heredity

基金内蒙古医学院第一附属医院重大课题

关键词雌激素受体基因多态性稽留流产 Estrogen receptorɑ gene Polymorphism Missed abortion

分类号 R714.21 [医药卫生—妇产科学]

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