摘要
目的了解地中海贫血(以下简称地贫)高发地区新婚夫妇地贫或基因携带者检出率及其婚配率的发生情况。方法采用血常规、Hb电泳分析和基因检测方法对13 880例(6940对)新婚夫妇及符合计划内待孕夫妇进行检测。结果 13880例中检出α地贫1955例,检出率14.08%,检出β地贫986例,检出率7.10%。α/α婚配夫妇255对,α/α配对率3.67%;β/β婚配夫妇40对,β/β配对率0.6%。结论地贫高发区存在较高的地贫或基因携带者的配对率。应加大地贫遗传危害健康教育,提高婚育人群婚前、孕前的地贫筛查率。
Objective: To learn the circumstancesthe of detectable rate and its marrage rate which young couple who live in the High-occurrence Thalassemia area got Thalassemia or carrying this gene.Methods: Cheaking 13 880cases(6940 couples) who are young couple and the couples for preparing pregnancy who conform to the birthing plan with blood routine,Hb analysis of electrophoresis and checking gene.Results: Detecting 1955cases α Thalassemia from 13 880cases,its detectable rate is 14.08%;and 986 α Thalassemia cases,its detectable rate is 7.10%.α/α married couples are 255 couples,α/α matching rate is 3.67%;β/β married couples are 40 couples,matching rate is 0.6%.Conclusion: The high matching rate of Thalassemia or carrying Thalassemia exist in the High-occurrence Thalassemia area.We should intensifies education which the hereditary is bad for health,improve Thalassemia Screening rate of married couples before marrying or pregnanting.
出处
《中国优生与遗传杂志》
2010年第10期106-107,119,共3页
Chinese Journal of Birth Health & Heredity
基金
国家科技支撑计划项目(课题号2006BAI05A02)
关键词
地贫筛查
新婚夫妇
地贫配对
Thalassemia Screening
Voung couple
Thalassemia matching