非心肌组织的短暂缺血对心肌的保护作用

Myocardial protection by brief ischemia in noncardiac tissue

短暂的心肌缺血可使心肌能耐受其后较长时间缺血，本文观察是否远处其它器官短暂缺血也能保护心肌。方法：心肌缺血预处理组（ＩＰＣ），３次短暂心肌缺血，每次５ｍｉｎ，其间间隔５ｍｉｎ；肠系膜动脉阻塞组（ＭＡＯ），ＭＡＯ１５ｍｉｎ，放松１０ｍｉｎ；股动脉阻塞组（ＦＡＯ）；股动脉结扎１５ｍｉｎ，放松１０ｍｉｎ。其后三组均阻塞在冠状动脉主干血流９０ｍｉｎ，再灌注１８０ｍｉｎ后将鼠杀死，用ＴＴＣ染色、观察坏死心肌的范围。结果：ＭＡＯ组、ＦＡＯ组、心肌ＩＰＣ组与假手术组相比心肌坏处面积明显缩小（Ｐ＜０．０１）．而前三组间心肌坏处面积则无显著性差异（Ｐ＞０．０５）。结论：短暂的肠系膜动脉、股动脉阻塞和心肌缺血预处理一样能有效保护心肌组织被长时间缺血，再灌注的损伤。

rief coronary artery occlusion (CAO) pretect myocardium. Whether ischemia in remote organs protects myocardium is unknown. 15 minutes (brief) occlusion of the mesensteric artery (MAO) and formal artery (FAO) can also protect against myocardial infarction as effectivelly as GAO. The present study may have important clinical implication , because it suggest that ischemia in remote organs could result in cardioprotection when it procedes a coronary thrombotic evetnt