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表皮生长因子受体在胃癌中的表达及意义 被引量:3

The expression and significance of epidermal growth factor receptor ingastric carcinoma
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摘要 采用免疫组化S-P法对75例胃粘膜标本进行表皮生长因子受体(EGFR)的检测。结果显示:正常胃粘膜EGFR均为阴性:EGFR的阳性率中重度异型增生组高于轻度异型增生组(P<0.05).进展期胃癌组高于早期胃癌组(P<0.05)。癌旁异常组织组高于癌旁正常组织组(P<0.05),有转移组高于无转移组(P<8.06);EGFR的表达与胃癌的组织学类型有关。结果提示,EGFR参与了胃癌的发生、发展,是胃癌前病变的一项有意义的标志物,并有助于判断胃癌预后。 - P immunohistochemical method was used to examine the expression of EGFR in 75 cases (5 normal gastric mucosas, 20 gastric mucosal dysplasias , 50 gastric carcinomas) and 27 paracarcinous tissues. The expression of EGFR was negative in 5 normal gastric mucosas. Statistically , the positive rates of EGFR in moderat and severe dysplasias , advanced gastric carcinomas , paracarcinous abnormal tissues and the group with metastasis were significantly higher than those in slight dysplasias , early gastric carcinomas, paracarcinous normal tissues and the group without metastasis, respectively. The results showed that EGFR positive expression might play an important role in the process of carcinogenesis of gastric mucosa and serve as a molecular marker of gastric premalignant lesions. The detection of E GFR is helpful for prognosis of gastric carcinoma.
作者 吴小翎
出处 《重庆医科大学学报》 CAS CSCD 1999年第2期135-137,共3页 Journal of Chongqing Medical University
关键词 表皮生长因子 受体 癌前病变 胃肿瘤 Epidermal growth factor receptor Gastric carcinoma Precancerous lesions Immunohistochemistry
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  • 1孙惠川,国外医学.肿瘤学分册,1995年,22卷,193页

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