表皮生长因子受体在胃癌中的表达及意义

The expression and significance of epidermal growth factor receptor ingastric carcinoma

采用免疫组化Ｓ－Ｐ法对７５例胃粘膜标本进行表皮生长因子受体（ＥＧＦＲ）的检测。结果显示：正常胃粘膜ＥＧＦＲ均为阴性：ＥＧＦＲ的阳性率中重度异型增生组高于轻度异型增生组（Ｐ＜０．０５）．进展期胃癌组高于早期胃癌组（Ｐ＜０．０５）。癌旁异常组织组高于癌旁正常组织组（Ｐ＜０．０５），有转移组高于无转移组（Ｐ＜８．０６）；ＥＧＦＲ的表达与胃癌的组织学类型有关。结果提示，ＥＧＦＲ参与了胃癌的发生、发展，是胃癌前病变的一项有意义的标志物，并有助于判断胃癌预后。

- P immunohistochemical method was used to examine the expression of EGFR in 75 cases (5 normal gastric mucosas, 20 gastric mucosal dysplasias , 50 gastric carcinomas) and 27 paracarcinous tissues. The expression of EGFR was negative in 5 normal gastric mucosas. Statistically , the positive rates of EGFR in moderat and severe dysplasias , advanced gastric carcinomas , paracarcinous abnormal tissues and the group with metastasis were significantly higher than those in slight dysplasias , early gastric carcinomas, paracarcinous normal tissues and the group without metastasis, respectively. The results showed that EGFR positive expression might play an important role in the process of carcinogenesis of gastric mucosa and serve as a molecular marker of gastric premalignant lesions. The detection of E GFR is helpful for prognosis of gastric carcinoma.