阴道分离假丝酵母菌耐药性变化研究

Study on the Change of Drug Resistance of Candida Mycoderma Isolated from Vagina

目的:研究合理停用伊曲康唑及特比萘芬对假丝酵母菌耐药性的影响。方法:对我院2008年7月～2009年10月门诊检出的假丝酵母菌进行菌株调查及耐药性分析。期间我院根据药敏结果进行了相关抗真菌药物的停用及恢复使用。结果:我院检出的致病性酵母菌中,白色假丝酵母菌占80.43%,光滑假丝酵母菌占17.44%。伊曲康唑对白色假丝酵母菌的敏感率由停药前的3.8%上升至停药后41.1%,特比萘芬对假丝酵母菌的敏感率停药前、后无明显变化。结论:合理停用抗菌药物可恢复假丝酵母菌对其的敏感性,不同药物恢复敏感性所需的时间不同。

OBJECTIVE：To investigate the effect of reasonable withdrawal of itraconazole and terbinafine on the drug-resistance of candida mycoderma.METHODS：The strain types and drug-resistance of detected candida mycoderma in out-patient department of our hospital from Jul.2008 to Oct.2009 were analyzed.Based on the results of drug susceptibility test,relevant behavior of antifungal drugs withdrawal and recovering the application of antifungal drugs were performed in our hospital.RESULTS：Of total detected pathogenic yeasts,candida albicans accounted for 80.43% and candida glabrate for 17.44%.The sensitivity rate of candida albicans to itraconazole went up from 3.8% to 41.1% after withdrawal while the sensitivity to terbinafine had no evident change.CONCLUSION：Rational withdrawal of antibacterials contributes to recover the drug sensitivity of candida mycoderma against antibiotics and the recovery duration of sensitivity to different drugs varies.