重组人干扰素α-2b注射液治疗老年肛周尖锐湿疣疗效观察

Efficacy Observation of Recombinant Human Interferon α-2b Injection in the Treatment of Condyloma Acuminatum in Elderly Patients

目的:观察重组人干扰素α-2b注射液治疗老年肛周尖锐湿疣患者的疗效。方法:104例老年肛周尖锐湿疣患者随机分为治疗组(61例)与对照组(43例),治疗组给予CO2激光治疗的同时,予以重组人干扰素α-2b注射液行疣体基底部及周围皮下局部注射,隔日1次,连续治疗10次。对照组只给予CO2激光治疗。结果:治疗后随访3个月,治疗组复发3例,复发率4.9%,对照组复发17例,复发率39.5%,经卡方检验,P<0.01,差异有统计学意义;治疗组痊愈率为95.1%,明显高于对照组(60.5%),经卡方检验,P<0.01,差异有统计学意义。结论:重组人干扰素α-2b注射液治疗老年肛周尖锐湿疣疗效显著。

OBJECTIVE：To observe the efficacy of Recombinant human interferon α-2b injection in the treatment of condyloma acuminatum in elderly patients.METHODS：104 elderly patients with condyloma acuminatum were randomized into treatment group（61 cases）and control group（43 cases）.Both groups received CO2 laser therapy.Treatment group were additionally given Recombinant human interferon α-2b injection at the base of wart and around it subcutaneously once every two days for 10 times.RESULTS：3 months of follow-up study was carried out after treatment.3 cases of recurrence was detected in treatment group with recurrence rate of 4.9%,17 cases of recurrence in control group with recurrence rate of 39.5%.There was statistical significance in difference via chi-square test（P0.01）.The cure rate of 95.1% in treatment group was significantly higher than in control group（60.5%）.There was statistical significance in difference via chi-square test（P0.01）.CONCLUSION：Recombinant human interferon α-2b injection has significant effect on condyloma acuminatum in elderly patients.