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风湿宁对佐剂性关节炎大鼠关节破坏的保护作用

Effect of Feng-Shi-Ning on Regulating the Expression of uPA and MMP-3 in Adjunvant Arthritis Rats
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摘要 目的:探讨中药复方风湿宁(FSN)对实验性类风湿性关节炎(RA)的疗效及作用机理。方法:以佐剂性关节炎(adjunvant arthritis,AA)大鼠为实验对象,分别予以FSN与雷公藤多甙(TWP)进行治疗,对照观察大鼠关节内病理组织学变化情况。采用免疫组织化学检测各组AA大鼠病变关节组织中uPA、MMP-3的表达。结果:FSN可显著抑制AA大鼠病变关节滑膜炎症与增生,防止关节软骨及骨质的破坏;FSN能明显降低uPA、MMP-3在AA大鼠软骨、骨组织及滑膜组织的表达(P<0.05或P<0.01)结论:FSN具有防止RA关节破坏的作用,其作用与阻断蛋白酶系统对软骨、骨基质成分的降解有关。 Objective：To observe the therapeutic effect of Feng-Shi-Ning（FSN） against adjuvant-induced arthritis in rats,as well as the mechanism.Methods：Take the adjunvant arthritis（AA） rats as animal model for RA,which were treated with FSN and tripterygium wilfordii polyglycosidum（TWP） respectively.And the expression of uPA and MMP-3 were observed by immunohistochemical examination.Results：FSN could prevent the joint cartilage and bone from destruction.The expression of uPA and MMP-3 were observed on synovium and chondrocyte.FSN could decrease the leveles of uPA and MMP-3（P0.01）.Conclusions：The data showed that FSN has inhibitory effects on symptom and condition of experimental RA,the anti-inflammatory effect is related to its adjustment effect on the expression of MMP-3 and uPA.
作者 黄映红 张耿豪 曾洁萍
机构地区 成都中医药大学基础医学院 成都博翎医药科技有限公司 成都中医药大学附属医院
出处 《成都中医药大学学报》 2010年第3期57-59,共3页 Journal of Chengdu University of Traditional Chinese Medicine
关键词 风湿宁 佐剂性关节炎 基质金属蛋白酶3(MMP-3) 尿激酶型纤溶酶原激活物(uPA) Feng-Shi-Ning Adjunvant arthritis Rheumatoid arthritis MMP-3 urokinase type plasminogen activator（uPA）
分类号 R285.5 [医药卫生—中药学]
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参考文献7

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成都中医药大学学报
2010年 第3期

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