摘要
目的：探讨吸入一氧化氮（ＮＯ）和静滴前列腺素Ｅ１（ＰＧＥ１）对急性肺动脉高压的治疗作用。方法：通过静脉持续滴注血栓素类似物Ｕ４６６１９复制犬急性肺动脉高压实验模型，观察静滴小剂量ＰＧＥ１１０ｎｇ／（ｍｉｎ·ｋｇ），大剂量ＰＧＥ１５０ｎｇ／（ｍｉｎ·ｋｇ）和吸入体积分数为４．０×１０－５ＮＯ及合并ＰＧＥ１１０ｎｇ／（ｍｉｎ·ｋｇ）对急性肺动脉高压的血流动力学影响。结果：小剂量ＰＧＥ１使肺动脉平均压（ＭＰＡＰ）下降（１７±８）％，体动脉平均压（ＭＳＡＰ）下降（１９±１０）％，心排量（ＣＯ）明显改善［（１．２１±０．２５）Ｌ／ｍｉｎｖｓ（１．８３±０．２７）Ｌ／ｍｉｎ，Ｐ＜０．０１］；大剂量ＰＧＥ１使ＭＰＡＰ下降（２９±７）％，ＭＳＡＰ下降（４１±１１）％，ＣＯ呈明显下降趋势［（１．２１±０．２５）Ｌ／ｍｉｎｖｓ（１．０４±０．３８）Ｌ／ｍｉｎ，Ｐ＜０．０５］；吸入ＮＯ４．０×１０－５以后，ＭＰＡＰ下降（２３±６）％，而ＭＳＡＰ无明显变化，ＣＯ上升不明显［（１．３４±０．１７）Ｌ／ｍｉｎｖｓ（１．４３±０．２４）Ｌ／ｍｉｎ，Ｐ＜０．０５］；吸入ＮＯ４．０×１０－５合并小剂量ＰＧＥ１后，ＭＰＡＰ下降（３１±７）％，?
Objective: To compare the therapeutic efficacy between intravenous PGE 1 and inhaled NO in the treatment of acute pulmonary hypertension. Methods: In 7 dogs, pulmonary hypertension was induced by infusion of the thromboxane analogue U46619 to observe the effect of intravenous administration of small dose PGE 1 10 ng/(min·kg), large dose PGE 1 50 ng/(min·kg),inhaled NO 4 0×10 -5 and inhaled NO plus small dose PGE 1 on the hemodynamics of acute pulmonary hypertension. We measured the changes of hemodynamic variables after each drug given. Results: Intravenous administration of small dose PGE 1 resulted in a decrease in MPAP by (17±8)%, MSAP by (19±10)%, and an increase of CO from (1.21±0.25) L/min to (1.83±0.27) L/min( P <0.01). Intravenous administration of large dose PGE 1 resulted in a decrease in MPAP by (29±7)%, MSAP by (41±11)%, and CO from (1.21±0.25) L/min to (1.04±0.38) L/min ( P <0.05). Inhaled NO resulted in a decrease in MPAP by (23±6)%, but no significant changes of MSAP and CO were observed. Inhaled NO plus small dose PGE 1 resulted in a decrease in PAPm by (31±7)%, SAPm by (14±9)%, and an increase of CO from (1.34±0.17) L/min to (2.01±0.34) L/min ( P <0.01). Conclusion: Inhaled NO plus small dose PGE 1 can not only decrease pulmonary artery pressure significantly, but also dilate the system artery and improve cardiac function, which will be useful to blood infusion of other tissues.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1999年第3期173-175,共3页
Academic Journal of Second Military Medical University
