摘要
目的:探讨抑癌基因杂合性丢失(LOH)在食管癌发生发展中的作用。方法:应用聚合酶链反应技术对46例食管癌YNZ22位点和DCC基因数目可变的串联重复序列(VNTR)区进行了分析。结果:食管癌YNZ22位点LOH率为44.4%;DCC基因为32.1%。LOH与组织学类型、肿瘤大小、浸润深度和淋巴结转移无明显相关。结论:YNZ22位点和DCC基因的LOH参与了食管癌的发生发展。
Objective: To evaluate the role of loss of heterozygosity (LOH) at tumor suppressor genetic loci in the carcinogenesis of esophageal carcinoma. Methods: Polymorphic analysis of the genetic loci of YNZ22 and DCC containing a variable number of tandem repeat was performed in 46 surgically resected specimens of esophageal carcinoma with PCR. Results: LOH and YNZ22 and at DCC were detected in 44.4% and 32.1% of the cases of our series respectively. No significant correlation existed between the LOH at YNZ22 and DCC loci and the histological types, tumor size, systemic invasion and lymph node metastasis of the carcinoma ( P >0.05). Conclusion: Our findings suggest that LOH at YNZ22 and DCC genetic loci may be involved in the carcinogenesis of esophageal carcinoma.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1999年第4期291-293,共3页
Journal of Third Military Medical University
关键词
杂合性丢失
DCC基因
食管肿瘤
VNTR
esophageal carcinoma
variable number of tandem repeat
loss of heterozygosity
DCC genes