复发性单纯疱疹性角膜炎患者血清IL-2及SIL-2R水平的研究

Study on the levels of serum interleukin-2 and soluble interleukin-2 receptor in patients with recurrent simple herpetic keratitis

目的研究复发性单纯疱疹性角膜炎患者血清白细胞介素-2（IL－2）及其可溶性白细胞介素-2受体（SIL－2R）水平。方法本文测定了30例复发性单纯疱疹性角膜炎患者（实验组）和25例健康人（对照组）血清白细胞介素－2（IL－2）及其可溶性白细胞介素－2受体（SIL－2R）的水平。结果对照组IL－2的水平为5．41±1．45mg·L－1，实验组IL－2R水平为2．80±1.47mg·L-1,2组比较t＝2．90，P＜0．01，说明复发性单纯疱疹性角膜炎患者血清IL－2水平较对照组明显降低。对照组SIL－2R水平为90．86±17．90mg·L－1，实验组SIL－2R水平为171·46±19.30mg·L－1，2组比较t＝5．17，P＜0．01。复发性单纯疱疹性角膜炎患者血清SlL－2R水平较对照组显著升高。结论复发性单纯疱疹性角膜炎患者体内免疫功能紊乱，血清IL－2活性降低、SlL－2R水平升高可能是其原因之一，这也为免疫治疗提供了一定依据。

Objective To study the levels of serum interleukin-2 and soluble interleukin-2 receptor (SIL-2R) in recurrent patients with simple herpetic keratitis. Methods The interleukin-2 and soluble interleukin-2 receptor(SIL-2R) in 30 cases of recurrent simple herpetic keratitis experimental group and 25 cases of healthy persons (control group) were determined. Results The serum IL-2 level was 5. 41 ±1. 45mg±L -1 in normal group,and 2. 80±1. 47mg·L -1 in the patients with recurrent simple herpetic keratitis. The serum IL-2 level in recurrent simple herpetic keratitis was significantly lower than that in normal group (t=2. 90, P<＜0. 01 ). The serum SlL-2R level was 90. 86 ±17. 90mg· L -1 in normal group and 171. 46 ± 19. 30mg'· L －1 in the patients with recurrent simple herpetic keratitis. The serum SIL-2 level in recurrent simple herpetic keratitis was significantly higher than that in normal group (t = 5. 17, P＜0. 01 ). Conclusions Immune function of recurrent simple herpetic keratitis is lower than that of healthy people. A significant decrease in IL-2 level and a significant increase in SIL-2R level maybe one of causes of this condition. The findings can provide foundation for immunotherapy.