非小细胞肺癌MMP-9、TIMP-1的表达与转移预后的相关性研究

Expressions of MMP-9 and TIMP-1 in non-small cell lung cancer and the relations to metastasis and prognosis

目的研究NSCLC中MMP-9、TIMP-1的表达,探索其与淋巴结转移及预后的关系。方法采用组织芯片技术,结合免疫组化法检测113例NSCLC和20例肺炎性假瘤中MMP-9、TIMP-1的表达。结果 MMP-9、TIMP-1的表达在不同年龄、性别、是否吸烟、原发肿瘤大小、病理类型及分化程度间的差异无统计学意义;而在淋巴结转移、TNM分期和生存期差异有统计学意义(P<0.05)。结论 MMP-9、TIMP-1的表达与NSCLC淋巴结转移、临床分期和预后密切相关,可作为判断NSCLC转移和预后的指标。

Objective To detect the expressions of MMP-9 and TIMP-1 in non-small cell lung cancer （NSCLC）,and to explore their relations to metastasis and prognosis of NSCLC.MethodsA tissue chip was made by the samples from 113 cases of NSCLC and 20 cases of inflammatory pseudotumor.The expressions of MMP-9 and TIMP-1 of the tissue chip were detected by immunohistochemical staining.ResultsThe expressions of MMP-9 and TIMP-1 were not significantly related to patient’s age,sex and smoking situation,and tumor’s size,histological type and differentiation.However,the expressions of MMP-9 and TIMP-1 were closely correlated with lymph node metastasis,TNM and life span stages of the patients with NSCLC.ConclusionsThe expressions of MMP-9 and TIMP-1 could serve as parameters for predicting metastasis and prognosis of NSCLC.