摘要
目的探讨藻酸双酯钠（ＰＳＳ）对肺炎病儿细胞黏附分子表达的影响。②方法采用ＥＬＩＳＡ法，检测了应用ＰＳＳ治疗前后肺炎病儿外周血白细胞ＣＤ１８的表达、血清可溶性细胞间黏附分子－１（ｓＩＣＡＭ－１）和可溶性血管细胞间黏附分子－１（ｓＶＣＡＭ－１）浓度的变化。③结果肺炎病儿外周血白细胞ＣＤ１８表达、ｓＩＣＡＭ－１和ｓＶＣＡＭ－１浓度明显增高，与对照组比较差异均有极显著性（ｔ＝６．２７０～９．８８２，Ｐ均＜０．００１）。应用ＰＳＳ治疗后白细胞ＣＤ１８表达、ｓＩＣＡＭ－１和ｓＶＣＡＭ－１明显降低，与治疗前和普通治疗组比较差异均有极显著意义（ｔ＝７．５５２～６９．９３０，Ｐ均＜０．００１）。④结论ＰＳＳ能明显降低肺炎病儿细胞黏附分子表达。
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Objective \ To explore the effects of polysaccharide sulfate(PSS) on the expression of cell
adhesion molecules in children with pneumonia.\ Methods \ By using enzymelinked
immunosorbent assay(ELISA), the leukocyte CD18 expression, the concentrations of serum
soluble intercellular adhesion molecule1(sICAM1) and soluble vascular cell adhesion
molecule1(sVCAM1) were measured in children with pneumonia before and after treatment with
PSS. \ Results \ The leukocyte CD18 expression, sICAM1 and sVCAM1 concentrations were
significantly higher in pneumonia children than those in controls(t=6.270-9.882, P<0.001), and
these indicators in pneumonia children after treatment with PSS were significantly lower than
those before treatment and those with common treatment(t=7.552-69.930, P<0.001).\ Conclusion
\ PSS could markedly decrease the expression of cell adhesion molecules in children with
pneumonia. \
出处
《青岛医学院学报》
1999年第1期30-31,共2页
Acta Academiae Medicinae Qingdao Universitatis
关键词
藻酸双酯钠
细胞黏附分子
肺炎
儿童
polysacchride sulfate
cell adhesion molecules
pneumonia
children
