妊娠早期人体胎盘中多巴胺-β-羟化酶活性的测定

DETERMINATION OF DOPAMINEBHYDROXYLASE ACTIVITY IN HUMAN PLACENTA AT EARLY STAGE

目的探讨妊娠早期人体胎盘中多巴胺－β－羟化酶（ＤＢＨ）活性及其与早期妊娠的关系。②方法应用分光光度法对妊娠６～９周人体胎盘绒毛中ＤＢＨ活性进行了测定。③结果妊娠第８周胎盘绒毛中ＤＢＨ的活性明显高于第６，７周，差异有显著性（Ｆ＝５．７６，ｑ＝５．８８，３．６４，Ｐ＜０．０５，０．０１），其他各组间比较差异无显著性（ｑ＝０．０６～３．２４，Ｐ＞０．０５）。④结论妊娠早期人体胎盘中已存在着ＤＢＨ，并可能参与妊娠的维持。

\ Objective \ To study the activity of dopamineBhydroxylase(DBH) in human placenta at early pregnancy and its relationship with pregnancy.\ Methods \ Spectrophotometric method was performed to estimate the quantity of DBH in villous chorion between 6th and 8th week of pregnancy.\ Results \ The activity of DBH in human villous chorion increased along with the pregnant period, especially at early stage. The DBH activity of 8th week was significantly higher than that of 6th and 7th week(F=5.76,q=5.88,3.64,P<0.05, 0.01). No significant differences were found between other groups(q=0.06-3.24,P>0.05).\ Conclusion \ DBH existed in human placenta at early pregnant stage and was involved in the maintenance of pregnancy.\;