大鼠认知电位(类P3)的研究

Cognitive potential (P3-like) in normal rats

目的：探讨引导参数对动物认知电位（类Ｐ３）的潜伏期、波形和时程的影响，并将类Ｐ３电位与动物行为检测相对比，以阐明动物认知电位与行为活动的相关性，为老年痴呆提供诊疗基础。方法：采用正常大鼠测定听觉类Ｐ３、电迷宫条件反射，观察３种导联、两种声强、两种平均叠加次数对Ｐ３的影响，比较类Ｐ３与电迷宫结果的关系。结果：不同的引导参数对类Ｐ３的潜伏期无显著影响。正常大鼠类Ｐ３与电迷宫条件反射有相关性。结论：应用类Ｐ３评大鼠认知、记忆功能有重要参考价值，对临床检测Ｐ３时选择引导参数有一定参考意义。

AIM and METHOD:To investigate the effect of leading parameters on the event-related-like potential (P3-like potential) of rats with epidural electrodes and comparison it with animal behavior to elucidate the correletion between the cognitive funotion and behavior.RESULTS:Latencies of the P3-like potentials were not obviously influenced by different lead parameters. The amplitude of the P3-like potentials evoked by 105 dB sound pressure level sounds were also much larger than that by 100 dB sounds. The electric maze indicator had positive correlation with P3-like potentials.CONCLUSION:We take into consideration of the lead parameters when recording the P3-like potentials. The P3-like potential may be a valuable tool for expoloration of cognitive function.