心理干预联合舍曲林对强迫症患者生活质量的影响

Influence of Sertraline Combined with Psychological Intervention on Quality of Life in Patients with Obsessive-compulsive Disorder

目的探讨心理干预联合舍曲林对强迫症患者生活质量的影响。方法 60例强迫症患者随机分为研究组30例和对照组30例。研究组给予心理干预联合舍曲林治疗,对照组单用舍曲林治疗,观察8周。采用Yale-Brown强迫量表和生活质量综合评定问卷(GQOLI-74)分别于治疗前和治疗后8周来进行疗效和生活质量评定。结果心理干预联合舍曲林对患者强迫症状的改善好于单用舍曲林治疗(t=2.08,P<0.05),对躯体功能、心理功能和社会功能的改善明显优于单用舍曲林组(t=2.18,2.14,2.09;P均<0.05)。结论心理干预联合舍曲林可以更好的改善患者的生活质量。

Objective To explore the influence of Sertraline combined with psychological intervention on quality of life in patients with obsessive-compulsive disorder（OCD）.Methods A total of 60 patients with OCD were randomly divided into study group（n=30） and control group（n=30）.The study group were treated with psychological intervention combined with Sertraline,and control group were only treated with Sertraline.The effically and quality of life were measured with Yale-Brown obsessive-compulsive rating scale and general quality of life inventory-74（GQOLI-74） before and after 8 weeks treatment.Results Compared with control group,psychological intervention combined with Sertraline had better efficacy in treating OCD（t=2.08,P0.05）.Psychological intervention combined with Sertraline improved physical function（t=2.18）,psychological function（t=2.14） and social function（t=2.09） significantly than Sertraline group at the end of study（P0.05）.Conclusion Psychological intervention combined with Sertraline can better improve the quality of life in patients with OCD compared with single Sertraline.