摘要
目的了解前列腺素E1对肝硬化的治疗作用。方法确诊的肝硬化患者125例随机分为两组,治疗组63例用前列腺素E1100μg加入GS静滴,每日2次,对照组62例用一般保肝治疗,疗程1个月,观察肝功能及肝纤维化五项指标变化。结果疗程结束后,治疗组肝功能显著改善(P<005),肝纤维化五项指标明显降低(P<005),显著优于对照组(P<005)。结论前列腺素E1对肝硬化患者具有抗肝损害和抗肝纤维化的作用。
Objective:ToinvestigatethetherapeuticeffectofprostaglandinE1(PGE1)onlivercirrhosis.Methods:125patieatswithlivercirrrhosisweredevidedintotwogroups.Patientsinexperimentgroup(63cases)weretreatedwithPGE1100g(inG.S)iv.gtt.bid,andpatientsincontrolgroup(62cases)weretreatedwithsimpleliverprotectingmedicine.Thecourseoftreatmentlastedforamonth.Thechangesinliverfunctionandinthefiveindexesofliverfibrosiswereobserved.Results:Aftertreatment,patientsinexperimentgroupgotremarkableimprovementininliverfunction(P<005)andinthefiveindexesofliverfibrosis(P<005),and(P<005)theresultswerebetterthanthecontrol.Conclusion:PGE1hassureeffectsofresistingliverdamageandliverfibrosisonlivercirrhosiscases.
出处
《福建医药杂志》
CAS
1999年第2期3-4,共2页
Fujian Medical Journal