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脊椎动物中维生素C合成能力的研究进展 被引量:3

Evolution of Vitamin C Biosynthesis in Vertebrates
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摘要 维生素C(VC)广泛参与动物体内诸如羟化反应和氧化还原反应等多种生化反应。大多数脊椎动物具备VC合成能力,其中L-古洛糖酸-1,4-内酯氧化酶(GLO)是其生物合成的关键酶。GLO在体内合成位置随脊椎动物进化地位从低到高总体上呈由肾脏向肝脏转移,最后消失的趋势。GLO基因突变是导致某些脊椎动物无法合成Vc的原因。此外,GLO的活性还受物种、性别、发育阶段、季节变化以及食物中抗氧化剂的影响。然而,导致部分脊椎动物缺乏Vc合成能力的原因及其在进化中的重要意义仍需深入研究。 Vitamin C (Vc) plays important roles in many biochemical and physiological processes of animals, such as involved in hydroxylation and oxidation-reduction reactions. Most of vertebrates are able to synthesize Vc in vivo, and L-gulono-1, 4-1actone oxidase (GLO, EC 1. 1.3.8) is the key enzyme at the last step of the biosynthesis. Some taxonomic groups of vertebrates lack the capacity of Vc biosynthesis usually due to the mutation of GLO gene. The appearance or disappearance of GLO in animals seems to correlate with their evolutionary status. There is a trend that transition of GLO occur from kidney to liv- er, and then disappear, which is associated with animal evolution from lower to higher, and then the highest status. In addition, the activity of GLO in vertebrates changes with species, sex, developmental stages, seasons and foods. However, if there is a natural rule that regulates the co-evolution between vertebrates and their Vc biosynthesis needs further investigations.
出处 《中国海洋大学学报(自然科学版)》 CAS CSCD 北大核心 2010年第10期43-49,共7页 Periodical of Ocean University of China
基金 国家自然科学基金项目(30972262)资助
关键词 维生素C L-古洛糖酸-1 4-内酯氧化酶 脊椎动物 进化 vitamin C biosynthesis L-gulono-1, 4-1actone oxidase (GLO) vertebrate evolution
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