摘要
纤维蛋白溶解系统是凝血系统的重要组成部分,对于维持血液的流动性和血管的完整性起着至关重要的作用。作为纤溶系统中心组分的纤溶酶原在其激活剂的作用下转变为活性形式的纤溶酶,进而降解纤维蛋白原,并能溶解血栓。纤溶酶也参与金属蛋白酶类和脂氧合酶类激活作用,还与细胞许多迁移相关的生理和病理过程相关诸如癌症、血管增生、卵子成熟、胚胎发生、伤口愈合以及病原侵入相关。本文简要概述了纤溶酶原和纤溶酶的结构、功能及其进化的研究进展。
The fibrinolytic system is an important part of the coagulation system and plays a vital role in the blood flowability and vascular integrity. The central component in the fibrinolytic system is the glycoprotein plasminogen, which is converted to the active enzyme plasmin by a plasminogen activator and then hydrolyzes fibrinogen and dissolves blood clots. Plasminogen activation also plays a major role in the activation of metalloproteinases and lipoxygenase, thereby linking to many physiological and pathological processes involved in cell migration such as cancer metastasis, angiogenesis, ovum maturation, embryogenesis, wound healing and pathogen invasion. This paper briefly reviews the progress of study on the structure, function and evolution of plasminogen.
出处
《中国海洋大学学报（自然科学版）》
CAS
CSCD
北大核心
2010年第10期69-74,共6页
Periodical of Ocean University of China
基金
国家自然科学基金项目(30972274)资助
