术前新辅助化疗治疗早期宫颈癌的研究

Neoadjuvant Chemotherapy before the Surgery of Early Cervical Cancer

目的探讨ⅠB2～ⅡB期宫颈癌术前应用新辅助化疗的疗效。方法收集我院2000-2007年间ⅠB2～ⅡB期宫颈癌而行手术治疗患者100例,其中50例在手术前行新辅助化疗1～2疗程(A组),50例在手术前未行新辅助化疗(B组)。比较2组的化疗疗效及手术疗效。结果新辅助化疗的总有效率为70%,可有效改善患者临床分期:A组与B组之间的术后盆腔淋巴结阳性率及宫旁脉管癌栓发生率之间的差异有统计学意义(P<0.05)。结论新辅助化疗可有效改善宫颈癌临床分期,显著提高宫颈癌手术疗效。

Objective To investigate the treatment effects of neoadjuvant chemotherapy before the surgery of stage ⅠB2～ⅡB cervical cancer.Methods 100 cases of cervical cancer in stage ⅠB2～ⅡB were operated in our hospital from 2001 to 2007,they were randomly divided into Group A（50 cases）who received neoadjuvant chemotherapy for 1-2 cycles before surgery,and Group B（50 cases）who were directly had an operation.We compared the treatment effects.Results The overall response rate was 70%,which can improved the cancer ＇s clinic stage.The rates of positive pelvic lymph node metastasis and parametrial invasion in Group A were significantly less than those in Group B（P〈0.05）.Conclusion Neoadjuvant chemotherapy can improve the stage of cervical cancer and the surgery effect.