代谢综合征大血管病变与PAI-1、hs—CRP水平及心脑血管危险因素相关性研究

The association of macroangiopathy with levels of PAI-I and C-reactive protein and cerebra-cardiovascular risk factors in metabolic syndrome

目的研究代谢综合征大血管病变患者血浆纤溶酶原激活物抑制物-1（PAI-1）、血清超敏C反应蛋白（hs—CRP）水平变化和意义。方法检测77例代谢综合征患者（其中大血管病变患者40例，无并发症患者37例）PAI-1、hs—CRP及血糖、血脂、游离脂肪酸（FFA）等生化指标水平，与30例健康对照组比较，并进行各指标之间的相关分析。结果代谢综合征大血管病变组患者PAI-1、hs—CRP水平明显高于正常对照组及无并发症组，且差异有统计学意义（P〈0．01）。结论PAI-1、hs—CRP水平与代谢综合征大血管病变有密切关系，PAI-1、hs—CRP水平检测对代谢综合征大血管并发症的诊断、预防和治疗具有很好的价值。

Objective To explore 1he changes in levels of plasminogen activator inhibitor-1 （ PAI-1 ） and C-reactive protein （ CRP ） in patients with metabolic syndrome and their significance. Methods Levels of hs - CRP, PAI-1 and blood glucose, lipids, and FFA were determined in 77 patients with metabolic syndrome （ 40 with macroangiopathy and 37 with no complications ） and 30 healthy subjects and then were compared. Results Levels of he - CRP and PAI-1 were significnatly higher in the group with macroangiopathy than in the group with no complications and the control group （ P〈0.01 ）. Conclusions Levels of hs - CRP and PAl-1 are closely related with macroangiopathy in metabolic syndrome, the diagnosis , treatment and prevention of metabolic syndrome with macorangiopathy.