异烟肼致药物热1例并文献复习

A case report of isoniazid-induced drug fever and review of literatures

目的探讨异烟肼致药物热的临床特点、发病机制和治疗。方法同顾性分析1例口服异炯肼抗结核治疗后出现发热病例的临床表现、诊断和治疗方法，结合文献复习。结果1例10岁男性患者，诊断为肠结核，在口服常规剂量异烟肼0．3gQd后当天出现发热的症状，为稽留热，停药后体温恢复正常，诊断为异烟肼致药物热。结论异烟肼致药物热为临床少见的药物不良反应，在异烟肼应用过程中出现用原发病不能解释的高热时，应高度注意此种药物不良反应的发生。治疗以对症处理为主，明确诊断后应停药。

Objective To explore the clinical features, pathogenesis, and treatment of iso- niazid-induced drug fever. Methods The clinical manifestations, diagnosis, and treatment of a patient who occmwed fever after receiving isoniazid therapy for tuberculosis were retrospectively analyzed and the relevant literatures were reviewed. Results A 10-year-old boy developed continuous fever on the day he took 300 mg isoniazid after being diagnosed as intestinal tuberculosis. His temperature returned to normal after discontinuation of the drug and he was diagnosed as drug fever induced by isoniazid. Conclusions Isoniazid-induced drug fever induced is a rare drug adverse reaction. This adverse reaction should be considered if unexplainablefever occured in the process of isoniazid use. The treatment is mainly focused on patients, symptoms and the drug must be discontinued.