冠心病患者血尿酸水平与不同方法评价的冠脉病变程度相关性分析

Association between serum uric acid level and the severity of CAD

目的 探讨血清尿酸水平与不同方法评价的冠脉病变严重程度的关系.方法 对心血管内科住院并行冠状动脉造影检查的515例患者资料进行分析,按照冠脉造影结果分为冠心病组和冠脉造影结果正常组,冠心病组分别按照SYNTAX评分等级及冠脉病变血管支数评价病变程度,分别分析比较冠脉造影结果正常组与不同病变程度组的尿酸水平的差异.结果 血尿酸水平冠心病组（347.23±88.10）μmol/L,正常组（359.99±100.79）μmol/L,两组间的血尿酸水平比较差异无显著性（P＞0.05）.SYNTAX评分和冠脉病变血管支数作为冠脉病变严重程度的标准而进行的分析,结果显示①以SYNTAX评分值作为标准分组,高危组（399.42±128.48）μmol/L均高于正常组的（347.23±88.10）μmol/L、低危组的（348.39±80.16）μ mol/L、中危组的（399.42±128.48）μ mol/L（P＜0.05）;而造影结果正常组、低危组、中危组间的血尿酸比较差异无显著性（P＞0.05）.②以冠脉病变血管支数作为标准分组,造影结果正常组（347.23±88.10）μmol/L、单支组（342.79±89.38）μmol/L、两支组（368.49±98.72）μmol/L、多支组（364.01±108.35）μmol/L,比较差异无显著性（P＞0.05）.结论 冠心病合并高尿酸血症患者的冠脉SYNTAX评分高于正常尿酸水平冠心病患者,血尿酸独立地影响冠心病患者的冠脉病变严重程度,而单纯按照冠脉病变支数评价,未能发现血尿酸水平与冠脉病变程度之间相关性.

Objective To explore the association of serum UA level with the severity of coronary artery disease （CAD） assessed by different methods. Methods Five-hundred and fifteen patients with suspected CAD received coronary angiography and were divided into normal group and CAD group; the severity of CAD was assessed based on the SYNTAX score and the number of stenosis. Serum UA levels were compared between the normal and CAD group with different severity. Results The average UA level in high-risk group for SYNTAX score was significantly higher than that of in the normal, low-risk, or moderate-risk group; UA level did not differ significantly among the normal group and univessel disease, twovessel disease, and multi-vessel disease groups. Conclusions CAD patients with hyperuricemia have higher SYNTAX wores than those with normal serum UA level. Uric ac id is independently assoc iated with the severity of CAD. But this association can not he found as the severity of CAD was determined by the number of stenotic vessels.