喹诺酮类药物的合理用药及不良反应分析

Analysis on Rational Drug use and Adverse Reactions of Quinolones

目的 探讨喹诺酮类药物在临床使用中的不良反应,为临床科学合理用药提供相应对策.方法 选择2008年2月-2010年2月间有喹诺酮类药物不良反应的117例患者进行回顾性调查与分析.结果 117例喹诺酮类药物不良反应患者主要由6种喹诺酮类药物引起,分别为：诺氟沙星、左氧氟沙星、环丙沙星、加替沙星、氧氟沙星、莫西沙星,其中诺氟沙星和左氧氟沙星分别占的41例和38例;不良反应的主要临床表现为皮疹、瘙痒、恶心、呕吐、腹痛、头晕、头痛、静脉炎等.结论 喹诺酮类药物是目前应用广泛的一类抗感染药物,但不良反应症状多;临床应用时要注意不良反应的监测,科学合理地用药,提高用药的安全性与疗效性.

Objective To investigate the adverse reaction of the clinical use of quinolones, and provede the clinical science with some rational countermeasures. Methods Selected 117 cases of adverse reactions of quinolones from February 2008 to February 2010, and surveyed and analyzed the cases in a retrospective way. Results The 117 cases of quinolone＇s adverse reactions were mainly induced by 6 quinolones. Norfloxacin and levofloxacin respectively accounted for 41 cases and 38 cases. The main clinical manifestations of the adverse reactions are rash, itching, nausea, vomiting, abdominal pain, dizziness, headache,phlebitis and so on. Conclusions Quinolones are the most widely used drug of anti-infection, but it can bring ltos of adverse reactions to the users. When use it in the clinical medicine, should pay attention to its adverse reactions, and use it Scientificly and rationally, to raise the safety and effect of the drug use.