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结直肠癌胸苷磷酸化酶的表达及其临床意义

Expression of thymidine phosphorylase in human colorectal carcinoma and its clinical significance
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摘要 目的:检测人结直肠癌组织TP的表达,以探讨其临床意义。方法:应用免疫组化S-P法检测结直肠癌组织62例(组织学分级:高分化组38例,中、低分化组24例,34例淋巴结转移,Dukes分期B～C期)和正常大肠组织24例TP的表达。结果:TP表达主要见于肿瘤细胞浆中,TP阳性表达41例,占66.1%,正常大肠组织TP阳性表达10例,占41.7%,正常大肠粘膜与结直肠癌组织中TP表达差异具有统计学意义(P<0.05);TP蛋白表达与患者年龄、性别、淋巴结有无转移以及不同组织学分级均无关(P>0.05)。结论:TP蛋白在结直肠癌组织中表达增强,为临床应用5-Fu类药物治疗结直肠肿瘤提供理论依据和指导意义。 Objective：To study the expression and clinical significance of thymidine phosphorylase （TP） in colorectal car- cinoma. Methods： Immunohistochemieal streptavidin/peroxidase techique was used to detect the expression of TP protein in 62 eases of coloreetal carcinoma and 20 eases of normal colorectal tissue. Results： TP protein expression was primarily observed in cytoplasm of the tumor cells. The expression of TP protein lind significant difference between the eoloreetal cancer group and the normal group. There was no significant difference among different ages, different sex, different his- tological grades and the group with lymph metastasis and that without （ P 〉 O. 05 ）. Conclusion： The expression of TP pro- tein is higher in eolorectal carcinoma and it can be used to guide the therapeutic effect of 5-Fu to the patients with color- ectal carcinoma.
作者 温达雄 黄慧敏
机构地区 河源市人民医院病理科
出处 《赣南医学院学报》 2010年第4期558-559,共2页 JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词 结直肠癌 胸苷磷酸化酶 免疫组织化学 colorectal carcinoma TP immunohistochemistry
分类号 R446.8 [医药卫生—诊断学]
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参考文献11

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二级参考文献10

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赣南医学院学报
2010年 第4期

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