药物性肝炎175例临床分析

An Clinical analysis of drug-induced liver disease

目的:分析175例药物性肝炎的病因和临床特征,加深对药物性肝炎的认识。方法:根据服药史、临床表现、肝功能、血清标志物及停药后的治疗效果等进行综合分析。结果:引起肝损害的药物中草药名列之首(26.3%)、依次为抗结核药(23.4%)、抗感染药(10.9%)、胃药(8.0%)、皮肤科用药(6.3%)、心血管药物(4.6%)、治疗甲亢药物(3.4%)、抗排斥药物(3.4%)、抗肿瘤药(2.9%)、治疗精神病药物(2.3%)、治疗骨质增生药(2.3%)、减肥药(1.7%)、治疗糖尿病药物(1.1%)、其他(3.4%)。结论:影响药物性肝炎的因素有药物的种类、用药时间、联合用药、患者的年龄和性别。

Objective ：To enhance the understanding of drug t,epatitis by analyzing the etiology and clinical feature of 175 eases with drug-induced liver disease. Methods：Clinical data of 175 patients with drug-induced hepatitis diagnosed from 2003 to 2008 werc reviewed. Medication history, clinical manifestations, liver function tests, serum markers and re- sponse of cessation of drug medication, and so on were studied with a view to find the causes and clinical features. Result： The etiological drugs were herbal medicine （26. 3%）, antituberculosis drugs （23. 4% ）, anti-infectious drugs （ 10.9% ） , digestant（ 8. 0% ） , drugs of dermatology（6.3% ）, cardiovascular drugs（4.6% ）, antithyroid drug（3.4% ）, anti-exclusion drugs （3.4%）, antineoplastic agent （2.9%）, anti-psychotic drugs （2.3%）, anti-hyperosteogeny drugs （2.3%）, weight-reducing aid（ 1.7% ） , diabetesg drugs（ 1.1% ） , and so on. Conclusion：The factors to influence drug hepatitis include the kinds of drugs to be used,duration of drugs used,combined use of drugs, age and gender.