摘要
目的:考察更昔洛韦与左氧氟沙星注射液配伍稳定性。方法:采用分光光度法测定25℃和37℃下配伍液中更昔洛韦及左氧氟沙星的含量变化,并在200~400nm进行紫外扫描,同时观察外观、pH值及微粒变化。结果:配伍液在8h内pH值、吸收峰峰形、峰位及微粒无明显变化,但颜色、含量及吸收峰峰值有变化。结论:临床应用时,二者需分开输注,不宜混合配伍应用。
Objective:To observe the changes of stability of ganciclovir and levofloxacin injection mixture at 25℃.Methods:The UV spectrophotometry was used to observe the changes of contents and absorption curves of the mixture in different time.The pH,appearance and particle of mixture were also observed.Results:There was no significantn change in pH,appearance and particle of mixture,but the contents and appearance of mixture had changed in room temperature within 8 hours.Conclusion:Ganciclovir and levofloxacin injection can not be mixed to use.
出处
《黑龙江医药》
CAS
2010年第5期726-727,共2页
Heilongjiang Medicine journal
关键词
更昔洛韦左氧氟沙星配伍稳定性
ganciclovir
levofloxacin injection
intermixture stability