克拉霉素微囊的制备工艺研究

Research on the preparation of clarithromycin microcapsules

目的:研究克拉霉素微囊的制备工艺,以提高儿童用药的顺应性。方法:以明胶为囊材,加入增塑剂,采用单凝聚法制备克拉霉素微囊。以微囊包封率、粒径和形态为评价指标,通过正交设计确定克拉霉素微囊的最佳制备工艺。结果:克拉霉素微囊最佳制备工艺为明胶液浓度40%,pH4,温度40℃,增塑剂与明胶用量比为0.25。结论:以最佳制备工艺条件制备含药微囊,重现性好,工艺稳定,口感得到极大改善。

Objective： Optimizing the preparation method for the clarithromycin microcapsules in order to increase the intaking compliance for children.Methods： Single-condensation method was employed to prepare microcapsules.Using Orthogonal Design Method to optimize the preparation technique by using encapsulation rate,particle size and shape as evaluating index.Results： The optimized technique： gelatin concentration 40%,pH4,temperature 40 ℃,ratio of plasticizer and gelatin 0.25.Conclusion： Clarithromycin microcapsules produced from the excellent technique had good repeatability.And the taste for the resulted product has also been improved greatly.