联合检测MPO与NT-proBNP在急性冠脉综合征中的临床意义被引量：2

Clinical value of combined assay of MPO and NT-proBNP in patients with acute coronary syndromes

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摘要目的:探讨髓过氧化物酶(MPO)与氨基末端脑钠肽前体(NT-proBNP)的联合检测对急性冠脉综合征(ACS)患者的危险性判断及预后评估的临床意义。方法:采用酶联免疫吸附法测定外周血MPO水平,电化学发光法检测NT-proBNP水平,比较ACS组与稳定型心绞痛(SAP)组及正常对照组的差异;随访90天、180天ACS患者近期心血管不良事件发生情况。结果:ACS组外周血MPO水平高于SAP组(P<0.05),SAP组与对照组之间差异无统计学意义(P>0.05);ACS组外周血NT-proBNP水平高于SAP组(P<0.05),SAP组高于对照组(P<0.05)。MPO与NT-proBNP单独检测时,ACS患者近期心血管不良事件发生率随着MPO或NT-proBNP浓度的增高而增高;MPO与NT-proBNP联合检测时,高MPO高NT-proBNP组90天、180天心血管不良事件发生率明显高于低MPO低NT-proBNP组(P<0.05)。结论:外周血MPO与NT-proBNP水平的升高均可提示ACS患者近期心血管不良事件的发生;联合检测外周血MPO与NT-proBNP水平对ACS患者的预后评估可能更具有临床价值。 Objective： To explore the clinical value of combined assay of myeloperoxidase（MPO） and N-terminal pro-brain natriuretic peptide（NT-proBNP） in patients with acute coronary syndromes（ACS） in prognosis evaluation.Methods： The peripheral blood levels of MPO and NT-proBNP were compared in the groups of ACS,stable angina pectoris（SPA）,and normal control,which were measured with enzyme-linked immunosorbent assay（ELISA） and electrochemiluminescence（ECL）,respectively.Cardiovasular events were recorded and compared in different groups when all patients were followed up during 90 days and 180 days.Results： The levels of MPO and NT-proBNP were higher in ACS group than in SAP and control group（P0.05）;but there was no difference of MPO between SAP and control group（P0.05）.The incidence of cardiovascular events during 90 days and 180 days increased with the levels of MPO or NT-proBNP.When the levels of MPO and NT-proBNP were combined,the incidence of cardiovascular events in patients with high levels of MPO and NT-proBNP was the highest.Conclusion： Either MPO or NT-proBNP can predict the short term prognosis of patients with ACS.The combined detection of MPO and NT-proBNP may have the most significant clinical value in predicting the short term prognosis of patients with ACS.

作者潘振华王惠民

机构地区上海梅山医院检验科南通大学附属医院医学检验中心

出处《江苏大学学报（医学版）》 CAS 2010年第5期401-404,共4页 Journal of Jiangsu University：Medicine Edition

关键词急性冠脉综合征髓过氧化物酶氨基末端脑钠肽前体预后评估 acute coronary syndromes myeloperoxidase N-terminal pro-brain natriuretic peptide prognosis evaluation

分类号 R543.3 [医药卫生—心血管疾病]

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