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6-氯哒嗪-3-甲酸甲酯的合成 被引量:2

Synthesis of Methyl 6-Chloropyridazine-3-carboxylate
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摘要 以乙酰丙酸乙酯为起始原料,经过环合、溴代、消除、重铬酸钾氧化、酯化、POCl3氯代6步反应合成6-氯哒嗪-3-甲酸甲酯,目标化合物总收率42%,本方法操作简单,成本低廉,分离纯化容易,收率高,为6-氯哒嗪-3-甲酸甲酯的规模化合成奠定了基础. Methyl 6-chloropyridazine-3-carboxylate (1) is a key intermediate in the research of anti-tumor,blood-lipid lowering and insecticides. In this article,methyl 6-chloropyridazine-3-carboxylate (1) is synthesized by using ethyl levulinate as starting material via a six-steps process including cyclization,bromination,elimination,oxidation,esterification and chlorination in the overall yield of 42%. This method is easy to operate and purificate with good yield,and the starting material is cheap. It has established a way to prepare methyl 6-chloropyridazine-3-carboxylate (1) on a large scale.
出处 《有机化学》 SCIE CAS CSCD 北大核心 2010年第9期1383-1386,共4页 Chinese Journal of Organic Chemistry
关键词 6-氯哒嗪-3-甲酸甲酯 乙酰丙酸乙酯 合成 methyl 6-chloropyridazine-3-carboxylate ethyl levulinate synthesis
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