小儿支气管哮喘与免疫功能及微量元素关系的临床研究

Clinic Study on the Relationship between T_lymphocyte Subtype,Trace Elements and Infantile Bronchoasthma

通过临床对照研究，发现哮喘患儿血Ｔ淋巴细胞亚群Ｔ３、Ｔ４、Ｔ８及Ｔ４／Ｔ８比健康对照组显著低下（Ｐ＜０００５），而总ＩｇＥ则显著升高。患儿血中必需微量元素Ｚｎ、Ｓｅ、Ｃｒ、Ｓｒ及宏量元素Ｂ、Ｍｇ比健康对照组显著降低，而Ｆｅ、Ｃｕ、Ｃａ、Ｖ、Ａｌ、Ｃｏ及有害元素Ｃｄ则显著升高（Ｐ＜００５）。结果表明，小儿哮喘与人体免疫缺陷、部分微量元素降低及有害微量元素升高密切相关。提示：提高人体免疫功能、调节微量元素代谢失衡对提高哮喘防治效果有重要意义。

The cellular immune function and trace elements content in children with infantile asthma were studied.The results showed that the T_lymphocyte subtypes,including T 3,T 4,T 8 and T 4/T 8,in children with asthma were significantly lower than those of control group( P <0 005),and the total serum IgE level was obviously higher.The essential trace elements,including Zn,Se,Cr,Sr,B and Mg content,was significantly decreased,whereas Fe,Cu,Ca,V,Al,Co and the harm element Cd were increased( P <0 05).These results indicated that infantile asthma correlated with the body immunodeficiency,the decrease of some essential trace elements and the increase of some harm elements.It is suggested that the improvement of body immune function and the maintenance of trace element metabolic balance are very important in the prevention and treatment of infantile asthma.