3Bayer TA,Schafer S,Breyhan H,et al.A vicious circle:role of oxidative stress,intraneuronal Abeta and Cu in Alzheimer's disease[J].Clin Neuropathol,2006,25(4):163-171.
4Chang WP,Koelsch G,Wonq S,et al.In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors[J].J Neurochem,2004,89(6):1 409-1 416.
5Bergstrom CP,Sloan CP,Lau WY,et al.Carbamate-appended N-alkylsulfonamides as inhibitors of gamma-secretase[J].Bioorg Med Chem Let,2008,18(2):464-468.
6Best JD,Smith DW,Reilly MA,et al.The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl] -4-(2,5-difluorophenyl)cyclohexyl] -1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse[J].J Pharmacol Exp Ther,2007,320(2):552-558.
8Schenk D,Barbour R,Dunn W,et al.Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse[J].Nature,1999,400(40):173-177.
9Jianmin Zhang,Xiaobing Wu,Chuan Qin,et al.A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and β-amyloid plaques in a mouse model of Alzheimer's disease.Neurobiology of Disease,2003,14(3):365-379.
10Smith JV,Luo Y.Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761[J].J Alzheimers Dis,2003,5(4):287-300.
8Harper JD, Wong SS, Lieber CM, et al. Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease[J]. Biochemistry, 1999,38(28):8792.
9Jarrett JT, Berger EP, Lansbury PT. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzhe imer's disease[ J ]. Bichemistry,1993,32(18) :4693.
10Tomiyama T, Asano S, Suwa Y. Rifampicin prevents the aggregation and neurotoxicity of amyloid L protein in vitro [ J]. Biochem Biophys Res Commun, 1994,204(1)76.
4Lüihrs T,Ritter C,Adrian M,et al.3D structure of Alzheimer' s amyloid-β (1-42) fibrils[J].Proc Natl Acad Sci USA,2005,102:17342-17347.
5Kim C,Jang CH,Bang JH,et al.Amyloid precursor protein processing is separated regulated by protein kinase C and tyrosine kinase in human astrocytes[J].Neurosci Lett,2002,324 (3):185-188.
6Maillet M,Robert SJ,Cacquevel M,et al.Cros-stalk between Rapl and Rac results secretion of sAPP alpha[J].Nat Cell Biol,2003,5 (7):633-639.
7Wallin AK,Blennow K,Andreasen N,et al.CSF biomarkers for Alzheimer ' s disease:levels of beta-amyloid,tau,phosphorylated tau relate to clinical symptoms and survival[J].Dement Geriatr Cogn Disord,2006,21 (1):131-138.
8Nelson O,Tu H,Lei T,et al.Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1[J].J Clin Invest,2007,117 (5):1230-1239.
9Town T,NikolicV,Tan J.The microglial“activation" continuum:from innate to adaptive response[J].J Neuroinflammation,2005,2:24.
10Hock C,Maddalena A,Rasching A,et al.Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42in patients with Alzheimer' s disease[J].Amyloid,2003,10:1-6.
