食管鳞癌中细胞角蛋白13的表达及临床意义

Expression and significance of cytokeratin 13 in esophageal squamous cell carcinoma

目的研究细胞角蛋白13(CK13)在食管鳞癌组织中的表达及临床意义。方法应用免疫组织化学SP法检测51例临床手术切除的食管癌标本及相应的食管黏膜标本中CK13的表达。结果 CK13在正常食管黏膜的表达为86.3%(44/51)、食管癌为31.4%(16/51),差异有统计学意义(P<0.01);CK13在高分化、中低分化鳞癌阳性表达为10例(19.6%)、6例(0.8%),在Ⅰ、Ⅱ期和Ⅲ、Ⅳ期中阳性表达分别为11例(21.6%)和5例(4.2%);在未浸润外膜和浸润外膜的鳞癌组织中阳性表达分别为12例(23.5%)和4例(7.8%),差异均有统计学意义(P<0.05)。结论 CK13在食管癌呈低表达,检测CK13在食管癌中的表达有利于对食管癌患者的诊断和预后进行评估。

Objective To investigate the expression and clinical significance of the cytokeratin 13 in esophageal squamous cell carcinoma.Methods The expression of CK13（CK13） in 51 cases of clinical specimens of esophageal cancer surgical resection and the corresponding esophageal mucosa was detected by immunohistochemistry SP method.Results The expression of CK13 in normal esophageal mucosa was 86.3%（44/51） and 31.4%（16/51） in esophageal cancer（P0.01）.The expression of CK13 in the well differentiated,the middle and poorly differentiated squamous cell carcinoma were 10 cases（19.6%） and 6 cases（11.8%）,respectively.The expression in stageⅠ,Ⅱand stageⅢ,Ⅳwere 11 cases（21.6%） and 5 cases（4.2%）,respectively.In addition,the expression in non-infiltration adventitia and infiltration adventitia were 12 cases（23.5%） and 4 cases（7.8%）,respectively. Conclusion The expression of CK13 in esophageal cancer was lower,and the detection of the expression of CK13 in esophageal cancer was beneficial for the evaluation of diagnosis and prognosis of esophageal carcinoma.