去甲万古霉素治疗粒细胞缺乏并发危重感染21例疗效分析

Norvancomycin Therapy for 21 Cases of Agranulocyte Complication with Severe Infection

目的观察去甲万古霉素治疗粒细胞缺乏并发危重感染患者的疗效。方法选择经大剂量化疗导致骨髓抑制,引起粒细胞缺乏合并危重感染的42例恶性血液病患者最为研究对象,随机分为两组,治疗组采用去甲万古霉素加1～2种其他抗菌药物,疗程5～10d;对照组采用单一亚胺培南/西司他丁或三代头孢联合喹诺酮类5～14d作为对照。结果两组的临床有效率分别为71.4%、52.3%,统计学分析表明,两组间疗效差异有统计学意义,治疗组去甲万古霉素不良反应较小。结论去甲万古霉素加1～2种其他抗菌药物在治疗化疗后粒细胞缺乏并发危重感染时有良好的疗效,且安全性较高。

OBJECTIVE To observe the curative effect of norvancomicin for patients occuring agranulocyte（ANC）.METHODS A total of 42 patients with ANC who had accepted high dosage chemiotherapy were randomly divided into 2 groups：norvancomycin group and control group.Norvancomycin0.8～1.6 g/d with 1～2 other antibiotics,the course was 5～10 days;and the course of the third cephalosporins combining with quinolones or imipenem was 5～14 days as contrast.RESULTS The clinical effect rates of the two groups were 71.4% and 52.3%,respectively.The side-effect of norvancomycin group was less serious.Statistics analysis showed that the difference between the two groups was statistically significant.CONCLUSION The therapy of Norvancomycin together with 1～2 other antibiotics shows good curative effect and presents a high security.