352例经尿道前列腺电切围手术期抗菌药物使用分析

Antibiotics Used in Peri-operation of 352 Cases with Transurethral Resection of Prostate

目的了解经尿道前列腺电切围手术期抗菌药物的使用情况，为临床合理用药提供指导。方法对2005年8月～2009年8月经尿道前列腺电切手术抗菌药物的使用进行回顾性调查、分析。结果352例经尿道前列腺电切术均应用抗菌药物，使用率达100．00％，抗菌药物以头孢羟氨苄（30．68％）为最多，氨曲南（4．83％）最少；术前30min给药为最多，为267例，占75．85%；抗菌药物应用疗程为3～10d，平均5．3d，疗程3d为最多，占60．23％，疗程10d为最少，占12．78％；术后医院感染率为4．26％。结论医院对经尿道前列腺电切术抗菌药物的应用给药时间和疗程较为规范、合理，医院感染率控制在较低水平，但预防用药的类别比较高，有待于进一步控制。

OBJECTIVE To provide guideline for clinical medication usage through investigating the antibiotics used in the peri-operation of 352 cases of transurethral resection of prostate （TURP）. METHODS The TURP operations between Aug 2005 and Aug 2009 were investigated and analyzed. RESULTS The results showed that antibiotics were applied in all of the 352 TURP cases （100. 00%）. The third generation of cephalosporin was the main category of the antibiotics, and it accounted for 32. 95%. The antibiotics applied 30 minutes before the operation, which occupied 75.85 %. The period of taking medicines normally lasted for three to ten days with the average of 5.3 days. The infection rate after the operation was 4. 26%. CONCLUSION The time and course of application of antibiotics in TURP cases in hospital are relatively reasonable. The control of nosocomial infection is at a relatively low level,but the category rate of preventive application is relatively high, which needs to be further controlled.