湖北地区鲍氏不动杆菌的临床分布及耐药性分析

Monitoring of Clinical Distribution and Drug Resistance in Acinetobacter baumannii Strains in Hubei Province

目的监测2005-2006年湖北地区16所医院临床分离鲍氏不动杆菌(ABA)的分布及耐药性。方法收集1546株鲍氏不动杆菌临床株,对其标本来源、病区分布及检出率进行调查,采用K-B法测定所有菌株对14种抗菌药物的敏感性,采用WHONET5.3进行数据分析。结果 1546株菌株主要来源于痰标本(76.7%);病区主要来源于内科(34.2%);ABA对头孢哌酮/舒巴坦的耐药率最低,为15.7%,其次为亚胺培南18.0%和美罗培南31.7%;对其余11种抗菌药物的耐药率均在53.3%～79.8%;共检出亚胺培南耐药株263株,泛耐药株(PDRS)6株。结论应加大对ABA耐药性的监控力度,预防ABA医院感染暴发流行。

OBJECTIVE To monitor the distribution and antimicrobial resistance of clinical isolates of Acinetobacter baumannii（ABA）strains from the sixteen hospitals in Hubei Province from 2005 to 2006.METHODS A total of 1546 clinical isolates of ABA strains were collected.Sample′s source,department distribution and detection rate were investigated.The K-B methods were adopted to detect 14 antibiotics′ susceptibility.Drug sensitivity results were analyzed by WHONET5.3.RESULTS Samples were mainly from sputum（76.7%）;the most of department distribution was medical department（34.2%）.Cefoperazone/sulbactam showed the lowest drug resistance（15.7%）,followed by imipenem（18.0%） and meropenem（31.7%）.The drug resistance rate of the remaining 11 antibiotics were all between 53.3% and 79.8%.Altogether 263 imipenem resistant strains and 6 pan-drug resistant strains were detected.CONCLUSION The monitoring to the drug resistance of A.baumannii should be strengthened to prevent the outbreak of its nosocomial infection.