172株解脲脲支原体药敏试验结果分析

Drug Sensitivity Test for Ureaplasma urealyticum:An Analysis of 172 Strains

目的了解湖州地区解脲脲支原体药敏的情况,为临床用药提供参考资料。方法用支原体分离培养药敏试剂盒对2007年8月-2009年3月的172株解脲脲支原体培养阳性的非淋菌性尿道炎患者菌株行药物敏感试验。结果四环素类的药物敏感性最高,米诺环素、多西环素和四环素药物敏感性分别为97.67%、97.09%、95.35%,差异无统计学意义;其次为大环内酯类,其中交沙霉素80.23%,克拉霉素为73.84%;喹诺酮类的药物敏感性最低。结论四环素类和大环内酯类药物中的交沙霉素和克拉霉素可作为临床治疗非淋菌性尿道炎的一线用药。

OBJECTIVE To collect the document about drug sensitivity in Ureaplasma urealyticum-infected cases in Huzhou area recently and to instruct drug-selecting in clinic treatment.METHODS Drug sensitivity test on 172 U.urealyticum-positive non-gonococcal urethritis（NGU）（mucopurulent cervicitis,MPC） cases was conducted by Mycoplasma IES Test kit from Aug 2007 to Mar 2009.RESULTS Tetracyclines performed the highest sensitivity,the sensitivity to minocycline,doxycycline and tetracycline was 97.67%,97.09%,and 95.35%,respectively without significant difference;followed by macrolides,such as josamycin（80.23%） and clarithromycin（73.84%）;quinolones had the lowest sensitivities.CONCLUSION Tetracyclines and macrolides（especially josamycin and clarithromycin） can be employed as the first-choice drugs in NGU（MPC） treatment,and quinolones should be avoided.