复方肿瘤血管生成抑制因子口服液对小鼠免疫功能的影响

Influence of Compound Oral Liquid of the TumorAngiogenesis Inhibitor on the Immunological Function in Mice

为探讨复方肿瘤血管生成抑制因子口服液（ＣＯＬ－ＴＡＩ）对正常及化疗小鼠免疫功能的影响，应用环磷酰胺（ＣＴＸ）对实验小鼠进行化疗或给实验小鼠以致死量的阿糖胞苷（ＡＲＡ－Ｃ），然后给小鼠口服ＣＯＬ－ＴＡＩ，比较用药组和对照组之间小鼠腹腔巨噬细胞Ｃ３ｂ受体活性、吞噬功能、淋巴细胞酸性非特异性酯酶和生存时间等免疫指标的影响．结果显示ＣＯＬ－ＴＡＩ可明显提高小鼠腹腔巨噬细胞Ｃ３ｂ受体性活，ＣＯＬ－ＴＡＩ对化疗小鼠的免疫缺损有恢复作用，可提高小鼠巨噬细胞吞噬率和吞噬指数，增加ＡＮＡＥ＋（α－乙酸苯酯酶＋）淋巴细胞百分率；ＣＯＬ－ＴＡＩ可显著延长给阿糖胞苷致死量小鼠的生命（Ｐ＜０．０１）．ＣＯＬ－ＴＡＩ具有增强正常和化疗小鼠特异性和非特异性免疫功能，口服ＣＯＬ－ＴＡＩ可显著提高化疗小鼠的免疫水平．

To research the influence of Compound Oral Liquid of the Tumor Angiogenesis Inhibitor (COL-TAI) on the immunological function in mice, some chemotherapy mice were established by cytoxan (CTX) ip and other mice were given cytarabine (ARA-C) with a lethal dose. After po of COL-TAI, the C3b receptor's activity, the phagocytose fuction and the survival time were compared, the percentage of ANAE+ lymyhocytes were calculated. The results showed that when COL-TAI is given orally, the C3b receptor's activity, the percentage and indexes of macrophagocytes from the mice's abdominal cavity were significantly enhanced (P<0.01), the percentage of ANAE+ lymphocytes increased (P<0.05), the immunodificiency of the mice with chemotherapy were recoved; COL-TAI prolonged the survival time of the mice which have been given ARA-C with a lethal dose. COL-TAI can improve the immunological function in mice with chemotherapy or not.