COX-2、VEGF、E-cad在乳腺癌中的研究进展

Study Progress on the Expression of Cyclooxygenase-2,Vascular Endothelial Growth Factor and E-cadherin in Breast Cancer

在乳腺癌演变的过程中,环氧化酶2诱导了乳腺癌的发生、发展;血管内皮生长因子促进了肿瘤血管的生成,保证了肿瘤细胞的生长与存活;上皮钙黏蛋白介导同型细胞之间的连接,其表达的降低或缺失可直接引起肿瘤细胞趋向离散,易于从原发灶脱落、转移。因此,检测这三个影响因子的表达和分析它们之间的关系对判断乳腺癌患者预后及指导临床个体化治疗有重要意义,同时也为临床治疗提供了新的思路与策略。

In the process of evolution in breast cancer,cyclooxygenase-2 induces the occurrence and development of breast cancer;vascular endothelial growth factor promotes the formation of tumor blood vascular,guarantees the growth of tumor cells to survive;E-cadherin mediates the connection between the same homotype cell,and its lower expression or loss may causes directly tumor cells to discrete,which is easy to fall from the primary and transfer.Therefore,it is significant for detecting the expression of various factors and analyse the relationship among them to judge patient outcomes and guide clinical tailored therapies and provides new ideas and strategies to clinical treatment.