氨基末端脑钠肽前体在心血管疾病诊治中的应用价值

Application Value of N-terminal pro-B-type Natriuretic Peptide in Diagnosis and Treatment of Cardiovascular Disease

脑钠肽同源代谢产物氨基末端脑钠肽前体(NT-proBNP)具有半衰期长、稳定性良好等优点,临床测定血浆NT-proBNP水平有重要意义,特别是在急性呼吸困难的鉴别诊断、心力衰竭早期诊断、治疗、预后判断中起着非常重要的作用。近年来发现,其对冠状动脉粥样硬化性心脏病的早期诊断及预后判断也有较高的应用价值,但在指导心力衰竭治疗方面尚缺乏循证医学证据。

Natriuretic peptide system plays an important role in the maintenance of cardiac structure and function,and most investigated is B-type natriuretic peptide（BNP）.N-terminal pro-B-type natriuretic pep tide（NT-proBNP）is the inactive metabolite of BNP,and it has a longer halftime and better stability than BNP.The detection of NT-proBNP plays an important role in clinical application,especially the differential diagnosis of acute dyspnea,and the diagnosis,treatment and prognosis of heart failure.These years,it was found to have high application value in the early diagnosis and prognosis of coronary heart disease.But the evidence of evidence-based medicine about the treatment of heart failure is also absent.