摘要
对159名中国辽宁汉族个体的基因组DNA进行分析,共检出42种等位基因,其中以DRB109012(12.8%)、0701(10.7%)、1501(10.4%)最为常见,其次为DRB11201(79%)、1202(75%)、1101(66%)、0301(5.0%)。并发现辽宁汉族人DRB1等位基因频率与白种人间存在明显差异,揭示不同人种有其自己的主要等位基因。
HLA- DRB1 alleles of 159 Chinese donors from Liaoning Han population were determined by using a set of 23 sequence specific oligonucleotide probes directed to various DRB1 alleles. The samples were first amplified and divided into 8 groups by allele/group specific primers. The SSOs enable us to identify 58 different DRB1 subtypes. 42 alleles were detected in the study of this population. Among them, the DRB1 *09012(12.8%), *0701(10.7%), *1501(10.4%), *1201(7.9%), *1202(7.5%), *1101(6.6%), *0301(5.0%) are the most frequent. The significant difference was found in Chinese northern Han population by comparing the gene frequencies in Caucasoid samples, suggesting that there were principal DRB1 alleles in different races.
出处
《遗传》
CAS
CSCD
北大核心
1999年第3期20-24,共5页
Hereditas(Beijing)
基金
国家教委留学归国人员科研基金
辽宁省科委自然科学基金