大黄虫丸治疗慢性肝炎后肝硬化47例临床观察

Clinical Observation of Pill of Da-huang Zhe-chong on Chronic Hepatitis after Hepatic Cirrhosis,A Report of 47 Cases

目的:观察大黄虫丸对慢性肝炎后肝硬化纤维化指标的改善情况。方法:将90例肝炎后肝硬化患者随机分为治疗组47例,对照组43例,治疗前后分别检测血清肝纤维化指标透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)、层黏蛋白(LN)的变化情况,并同时检测治疗前后肝功能和B超的情况,疗程为6个月。结果:治疗组血清肝纤维化指标四项均有明显下降(P<0.01,P<0.05),对照组只有HA下降显著(P<0.05),PCⅢ、Ⅳ-C、LN的变化与治疗前无显著性差异(P>0.05)。治疗组HA、PCⅢ、Ⅳ-C参数较对照组有显著性下降(P<0.01)。治疗后两组患者的肝功能指标均有不同程度的好转,两组ALT、AST、ALB无显著性差异(P>0.05)。治疗组多数患者的B超指标有好转(但P>0.05)。结论:大黄虫丸具有抗肝纤维化的作用,且疗效明显优于对照组。

Objective ： To observe the curative effect of Pill of Da - huang Zhe - chong on fibrosis indicators in hepatic cirrhosis of chronic hepatitis. Method ： 90 cases with hepatic cirrhosis after hepatitis were divided into treat- ment group （47 cases） and control group （43 cases） randomly. Before and after treatment HA,PCIII,IV- C and LN were detected,and at the same time the hepatic function and ultrasound B were detected too. The course of treatment included 6 months. Result ： HA,PCIII, IV - C and LN in treatment group were decreased remarkably （P 〈 0.01 ,P 〈 0. 05 ）. But only HA in control group was decreased markedly （P 〈 O. 05 ） , and PCIII, IV - C and LN did not show significant difference （ P 〉 0.05 ）. The hepatic function in the two groups were improved in different extent before and after treatment, but there was no significant difference between the two groups （ P 〉 0. 05 ）. Ultrasound B was improved among most of the cases in treatment group （P 〉 0. 05 ）. Conclusion： Pill of Da - Zhe - chong has the effect of anti - hepatic - fibrosis, and it is better than other treatment.