摘要
利用药剂学方法和栅控恒压电晕充电技术制备驻极体美洛昔康贴剂,考察驻极体美洛昔康贴剂经皮给药24 h内,美洛昔康在SD大鼠血液和肝脏组织中浓度的变化,探讨负极性驻极体对美洛昔康的透皮促渗效果.实验结果表明经皮给药24 h内,-2 000 V驻极体对美洛昔康的透皮促渗效果不明显;-1 200 V驻极体对美洛昔康的透皮吸收有明显的促渗作用,且促渗倍数为对照组4倍.
PP electret meloxicam patches were prepared by the corona charging and pharmaceutical method to study the concentration changes of drug in plasma and liver tissue within 24h after transdermal administration,and to investigate the enhancement of negative electret on transdermal absorption of meloxicam.The results indicated that-1 200 V electret had a remarkable enhancing effect on percutaneous absorption of meloxicam with the enhancing ratio of 4,but-2 000 V electret showed no obvious enhancement on meloxicam transdermal absorption.Therefore,-1 200 had much better enhancing effect on meloxicam transdermal absorption as compared with-2 000 V electret.
出处
《河北大学学报（自然科学版）》
CAS
北大核心
2010年第5期560-563,共4页
Journal of Hebei University(Natural Science Edition)
基金
国家自然科学基金资助项目(50577066
50977089)
军队"十一五"国际合作项目(06H022)
关键词
经皮给药
驻极体
美洛昔康
血药浓度
肝脏组织
transdermal administration
electret
meloxicam
plasma concentration
liver tissue
