电压门控Na^+通道亚型及其功能——新的研究热点

Subtypes and Functions of Voltage gated Na + Channel

依靠现代分子生物学技术及电生理的记录，探讨各种Ｎａ＋通道亚型在中枢与周边神经系统以及一些非兴奋性组织细胞中的分布、表达、突变及其对信息调控的功能特征，已成为当今神经生物学等学科发展中的一个研究新热点。本文将侧重对有关哺乳动物Ｎａ＋通道亚型的分类、在不同组织细胞中的分布及其表达调控的功能机制等一些研究进展做一简要的回眸。

Since 1990s, the research on voltage gated sodium channels have got rapid progress by the use of molecular biological and electrophysiological recording techniques. This communication presents a brief review on mammalian sodium channel involving classification, distribution, and mechanisms of expression regulation of various subtypes in the central and peripheral nervous system and other nonexcitable tissues.