延髓头端腹外侧区神经元电活动与心血管活动相干性的研究

THE COHERENCE ANALYSIS BETWEEN NEURONAL DISCHARGE IN THE ROSTRAL VENTROLATERAL MEDULLAAND THE CARDIOVASCULAR ACTIVITY IN RATS*

本文分析了大鼠延髓头端腹外侧区（ＲＶＬＭ）神经元单位电活动与心血管活动的相干性，观察了ＲＶＬＭ区神经元电活动对电刺激中脑防御反应区的诱发反应，以及对压力感受性反射的反应。并用ＦＦＴ对ＲＶＬＭ区神经元自发单位放电和血压波进行频域的相干性分析，以判断是否具有心节律。还分析了ＲＶＬＭ区单位放电变异性与心率变异性的相干性。结果显示：ＲＶＬＭ区大多数神经元对电刺激中脑防御反应区呈兴奋反应（６７％），７０％神经元放电活动被注射苯肾上腺素而升高的动脉血压强烈抑制，具有心节律的神经元占６４％，５０％神经元放电变异性与心率变异性的高频呈良好的相关。神经元电活动的频谱分析为深入研究心血管自主神经系统功能提供了一种新方法。

To analyze the coherence between neuronal discharges (ND) in the rostral ventro lateral medulla (RVLM) and the cardiovascular activity, we observed the neuronal discharge in RVLM responding to electric stimulation of the defense area of the midbrain. Fast Fourier transform (FFT) was performed to analyze the coherence between the signals of ND and blood pressure to determine if the ND were cardiac rhythmic. The coherence between ND variability (NDV) and heart rate variability (HRV) was also analyzed. The results showed: (1) majority of the neurons (67%) were excited responding to electric stimulation in the defense area of the midbrain; (2) the electric activity of about 70% of the neurons were substantially inhibited by administration of phenylephrine; (3) 64% of the neurons were actively synchronous with cardiac cycle; and (4) significant coherence between NDV and HRV in HF component was shown in a half of the neurons (50%). The coherence analysis thus provides a new tool to investigate the reg