摘要
在α氯醛糖麻醉的猫上，结扎左心室冠状动脉前降支（ＬＡＤ）一小分支，对动物胆囊浆膜面予以缓激肽（ＢＫ），可反射性地诱发血压、左心室内压升高、±ｄＰ／ｄｔｍａｘ增大、心率加快，同时用超声单晶片声纳测微系统记录局部心壁运动，发现ＢＫ可以反射性地引起ＬＡＤ小分支远端所支配的心肌运动功能减弱。电针内关穴对ＢＫ诱发的升压反应有抑制作用，并可改善局部心肌运动功能。静脉注射纳洛酮（０４ｍｇ／ｋｇ）能翻转电针效应。结果表明，电针能够抑制ＢＫ诱发的升压反应和改善局部心肌运动功能，该效应与内源性阿片肽有关。
The effects of electroacupuncture (EA) on the pressor response
and reversible myocardial dysfunction induced by application of bradykinin (BK) on the
gallbladder were studied in cats anesthetized with chloralose. The cardiovascular responses
evoked by application of BK included a pressor response, an increase of LVP and its
dP/dtmax, tachycardia and a decrease of local wall motion of the left ventricle with a supplying
branch of the left anterior descending coronary artery ligated beforehand. Following EA of
bilateral Neiguan acupionts, the pressor response of BK was inhibited, while the regional left
ventricle myocardial dysfunction was alleviated significantly. The effects of EA were reversed
by iv injection of naloxone (04 mg/kg). Our results indicate that EA has an inhibitory effect on
the BKinduced pressor and ischemic dysfunction, which may be related with endogenous opioid
peptide.
出处
《生理学报》
CAS
CSCD
北大核心
1999年第2期175-180,共6页
Acta Physiologica Sinica
基金
国家自然科学基金
关键词
胆囊
缓激肽
电针
升压反应
局部心壁运动
gallbladder
bradykinin
electroacupuncture
pressor response
local
ventricle wall motion
naloxone
