他汀类药物对急性心肌梗死患者肾功能的影响

Effect of statins on renal function in patients with acute myocardial infarction

目的回顾性分析阿托伐他汀、辛伐他汀、氟伐他汀对急性心肌梗死患者肾功能的作用。方法选择105例急性心肌梗死患者，其中服用阿托伐他汀（A组）27例、辛伐他汀（B组）26例、氟伐他汀（C组）26例，未服用他汀类药物（对照组）26例。观察各组患者在治疗2周前后总胆固醇（TC）、低密度脂蛋白C（LDL-C）、肾小球滤过率（GFR）的变化值及之间的相关性。结果A、B、C三组患者经治疗后TC、LDL-C、GFR均较治疗前有所改善，并且与对照组比较有统计学差异（P〈0．05），其中TC、LDL-C改善水平与GFR改善有相关性。结论阿托伐他汀、辛伐他汀、氟伐他汀对急性心肌梗死患者具有肾保护作用，该作用与其降脂作用有一定相关性。

Objective To analyze the effects of atorvastatin, simvastatin and fluvastatin on renal function in patients with acute myocardial infarction. Methods 105 cases of acute myocardial infarction were randomly divided into atorvastatin group （27 cases）, simvastatin group （26 cases）, fluvastatin group（26 cases） and control group （26 cases）. The correlation among total cholesterol（TC）,low density lipoprotein C （LDL-C）, glomerular filtration rate（GFR） was analyzed during two weeks. Results The TC, LDL-C and GFR in treatment groups after treatment were statistically lower than before （P〈 0. 05）. There was correlation between TC and LDL-C with GFR. Conclusions Atorvastatin, simvastatin and fluvastatin protect the renal function in patients with acute myocardial infarction,which is related with their lipid-lowing effects.