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甾体-17-酮肟的Beckmann裂解反应研究

Study on Beckmann Fragmentation of Steroid-17-One Oximes
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摘要 研究了甾体-17-酮肟(1a^1i)在PCl5/2,6-二甲基吡啶/CH2Cl2体系中的Beckmann裂解反应。反应得到的烯-腈化合物(2a^2i)是18-去甲基甾体的重要中间体,其结构经1HNMR,IR,MS和元素分析表征。实验结果表明,1的取代基和构型对反应结果没有明显影响。 Beckmann Fragmentation of Steroid-17-One Oximes were studied in CH2Cl2 homogeneous solution of the reagent PCl5/2,6-lutidine to give the corresponding alkylene-nitrile compounds（2a^2i）.2 were key intermediates of preparation 18-norsteroids.The structures of 2 were characterized by 1H NMR,IR,MS and elemental analysis.The experimental results showed that effect of substituents and stereochemistry on the Beckmann fragmentation was not observed.
作者 晏昶皓 祝曙英 林成刚 杲婷 史海健
机构地区 南京工业大学化学化工学院
出处 《合成化学》 CAS CSCD 北大核心 2010年第5期626-628,632,共4页 Chinese Journal of Synthetic Chemistry
基金 江苏省高校自然科学基金资助项目(05KJB-150039)
关键词 甾体-17-酮肟 Beckmann裂解反应 18-去甲基甾体 合成 steroid-17-one oxime Beckmann fragmentation 18-norsteroid synthesis
分类号 O629.2 [理学—有机化学]
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参考文献14

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合成化学
2010年 第5期

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