糖尿病肢体缺血后血管新生能力受损机制探讨

Mechanism of impaired angiogenesis after Diabetic limb ischemia

糖尿病血管病变是糖尿病的主要并发症，它是以侧支血管形成能力严重受损为特征的全身性疾病。大量的证据已表明糖尿病患者内皮祖细胞功能受损，非酶糖基化终产物蓄积，Wnt信号通路功能紊乱可能是糖尿病肢体缺血后血管新生能力受损的重要机制，本文就其机制做一探讨，为糖尿病治疗性血管新生提供了新策略。

Diabetic vascular disease is a major complication of diabetes, which is characterized by the formation of collateral vessels of serious damage to systemic disease. Substantial evidence have shown that timpaired endothelial progenitor cell function, non-enzymatic glycation end products accumulate, and Wnt signaling pathway dysfunction may be an important mechanism of impaired angiogenesis after the diabetic limb ischemic. This paper is to make a study of its mechanism, and to provides a new strategy for diabetes therapeutic angiogenesis.