氟哌啶醇对慢性精神分裂症患者泌乳素的影响

The effect of haloperidol on prolactin in chronic schizophrenia

目的：探讨氟哌啶醇对泌乳素的影响及其与临床疗效的关系。方法：采用固定剂量氟哌啶醇治疗慢性精神分裂症４５例，疗程１２周；在治疗前后评定阳性与阴性症状量表（ＰＡＮＳＳ），并用放射免疫法测查血浆中泌乳素（ＰＲＬ）浓度。结果：治疗后，患者ＰＡＮＳＳ总分，阳性、阴性症状分量表和一般情况分量表均显著降低（Ｐ＜０．０１）；治疗前患者ＰＲＬ较对照组显著降低，治疗后显著增高（Ｐ＜０．００１）。治疗前后泌乳素差值与ＰＡＮＳＳ阳性症状分减分值显著相关。治疗后，女性病人ＰＲＬ值显著高于男性。结论：氟哌啶醇能显著提高精神分裂症患者ＰＲＬ水平，并与临床疗效相关。

Objective: To examine the effect of haloperidol on plasma prolactin level and its relationship with clinical response. Method: Fortyfive patients with diagnosis of chronic schizophrenia were treated with a fixed dose of haloperidol for 12 weeks. The subjects were assessed with the PANSS scale before and after treatment. Plasma prolactin level was measured with radioimmune assay. Normal subjects were recruited as control for comparison of baseline prolactin level. Results: There were significant decrease in the PANSS total score, P,N & G subscore after treatment. The baseline prolactin level was significantly higher in patients than control. The prolactin level in patient group increased significantly after treatment and the increase was positively correlated with the reduction in the P subscore. The prolactin level was also significantly higher in female than male patients after treatment. Conclusion: The increase in plasma prolactin induced by neuroleptics could be sensitive biological marker to predict therapeutic response.