精神分裂症患者弓形虫感染状况调查

Toxoplasma gondii infection and schizophrenia

目的：了解精神分裂症患者弓形虫感染状况。方法：采用酶联免疫吸附法（Ｅｌｉｓａ）检测１４６例住院精神分裂症患者的弓形虫循环抗原（ＣＡｇ），抗弓形虫ＩｇＭ、ＩｇＧ，并与５６名正常人比较。结果：精神分裂症患者血清弓形虫抗体阳性率为４３．８４％，显著高于正常对照组的１６．０７％（Ｐ＜０．００５）。盐城地区健康人群弓形虫抗体阳性率是全国平均水平的２．７５倍。结论：研究表明，该地区属弓形虫感染高发地区。

Objective: To study the infection by toxoplasama gondii in schizophrenic patients. Method: 146 inpatients with diagnosis of schizophrenia were examined for toxoplasma gondii CAg and antitoxoplasma gondii IgM and IgG using ELISA and the results compared with 56 normal control subjects. Results: The positive rate of serum antitoxoplasma gondii antibody was significantly higher in the schizophrenic group (4384%) than control (1607%) (P<0005). The figure for the control subjects was in turn 275 times higher than the mean value across the country. Conclusion: The Yancheng area is having a high infection rate of toxoplasma gondii. Acute schizophrenic patients are particularly vulnerable.